Troy comes to the Florida from North Carolina where he earned his B.S. in Chemistry at the University of North Carolina at Chapel Hill in 2020. While at UNC, he conducted research improving tendon healing through desferrioxamine coated sutures under Dr. Paul Weinhold. After college, he was an Associate Scientist at Tergus Pharma for a year under the In Vitro Release Testing Department developing methods for IVRT analysis of topical pharmaceutical products. Troy joined the Prentice lab in the fall of 2021 working on novel mass spectrometry instrumentation and imaging mass spectrometry of biological samples.

Teaching Experience

• TA- CHM3120 – Introduction to Analytical Chemistry (UF, 2023)
• TA- CHM2046L – General Chemistry and Qualitative Analysis Lab (UF, 2022)
• TA- CHM2046L – General Chemistry and Qualitative Analysis Lab (UF, 2021)
• TA- CHEM 241 – Modern Analytical Methods for Separation and Characterization (UNC, 2018)

Publications

• Yu Tin Lin, Haohui Bao,Troy R. Scoggins IV, Boone M. Prentice, ChemRxiv: https://doi.org/10.26434/chemrxiv-2024-kxjgg. iMSminer: a data processing and machine learning package for imaging mass spectrometry.
• David V. Donndelinger, Tingting Yan, Troy R. Scoggins IV, Jonathan T. Specker, and Boone M. Prentice, Journal of the American Society for Mass Spectrometry, 2024, 35, 1556–1566.  De novo sequencing of phosphopeptides using a sequential charge inversion ion/ion reaction and electron capture dissociation workflow.
• Troy R. Scoggins IV, Jonathan T. Specker, Boone M. Prentice, Analyst, 2024, 149, 2459-2468. Multiple ion isolation and accumulation events for selective chemical noise reduction and dynamic range enhancement in MALDI imaging mass spectrometry
• Alexander Smith, Jonathan Specker, Katharine Hewlett, Troy R. Scoggins IV, Montana Knight, Abigail Lustig, Yanhong Li, Kirsten Evans, Yingchan Guo, Qianxuan She, Michael Christopher, Timothy Garrett, Ahmed Moustafa, Daria Van Tyne, Boone M. Prentice, Joseph Zackular, mBio, 2024, 15, e01656-23. Liberation of host heme by Clostridioides difficile-mediated damage enhances Enterococcus faecalis fitness during infection
• Julia R. Bonney, Woo-Young Kang, Jonathan T. Specker, Zhongling Liang, Troy R. Scoggins IV, Boone M. Prentice, Analytical Chemistry, 2023, 95, 17766-17775. Relative quantification of lipid isomers in imaging mass spectrometry using gas-phase charge inversion ion/ion reactions and infrared multiphoton dissociation

Presentations

• Scoggins IV, T. R., Flores, J., Lin, Y. T., Silverman, M. A., Zackular J. P., Prentice, B. M., Investigation of Microbial Metabolites and Their Potential for Impact in Early Life Immune System Development, Upcoming Poster Presentation, Proceedings of the 72nd ASMS Conference on Mass Spectrometry and Allied Topics, Anaheim, CA, June 2-6, 2024.
• PeBenito, A., Scoggins IV, T. R., Prentice, B. M., Zackular J. P., Metabolic markers of C. difficile infection in the setting of Inflammatory Colitis, Upcoming Poster Presentation, Digestive Disease Week (DDW), May 18-21, 2024
• Donndelinger, D. V., Yan, T., Scoggins IV, T. R., Prentice, B. M., Sequencing Phosphopeptides via a Novel Tandem Mass Spectrometry Workflow, 2024 University of Florida Interdisciplinary Center for Biotechnology Research (ICBR) Research Day, April 18, 2024.
• Donndelinger, D. V., Yan, T., Scoggins IV, T. R., Prentice, B. M., Sequencing Phosphopeptides via a Novel Tandem Mass Spectrometry Workflow, The Herbert Wertheim UF Scripps Institute Chemical Biology 6th Drug Discovery Symposium, April 15-16, 2024.
• Scoggins IV, T. R., Flores, J., Silverman, M. A., Zackular J. P., Prentice, B. M., Deciphering Microbial Metabolite Isomers: Implications for pTreg-Mediated Immune Regulation, Oral Presentation, University of Florida Department of Chemistry Leadership Board Meeting, April 12, 2024
• Scoggins IV, T. R., Flores, J., Silverman, M. A., Zackular J. P., Prentice, B. M., Examining the Microbiome’s Impact on Peripheral Regulatory T-cell Development in Early Life, Poster Presentation, University of Florida Graduate Student Research Day, April 2, 2024
• Donndelinger, D. V., Yan, T., Scoggins IV, T. R., Prentice, B. M., Sequencing Phosphopeptides via a Novel Tandem Mass Spectrometry Workflow, University of Florida Graduate Student Research Day, April 2, 2024.
• Scoggins IV, T. R., Flores, J., Silverman, M. A., Zackular J. P., Prentice, B. M., Exploring the Influence of the Microbiome on Immune System Maturation, Poster Presentation, University of Florida Emerging Pathogens Institute Research Day, February 15, 2024
• Donndelinger, D. V., Yan, T., Scoggins IV, T. R., Prentice, B. M., Peptide sequencing and phosphorylation site localization of MALDI-generated phosphopeptide anions enabled using a sequential charge inversion ion/ion reaction and ECD, Poster Presentation, Emerging Pathologies Institute Research Day, University of Florida, February 15, 2024.
• Scoggins IV, T. R., PeBenito, A., Specker, J. T., Zackular J. P., Prentice, B. M., Spatial metabolite mapping of Clostridioides difficile infection alongside Inflammatory Bowel Disease using imaging mass spectrometry, Poster Presentation, University of Florida Chemistry-Biology Interface Mini-Symposium, October 14, 2023
• Scoggins IV, T. R., PeBenito, A., Specker, J. T., Zackular J. P., Prentice, B. M., Exploring potential biomarkers for Clostridioides difficile infection in tandem with Inflammatory Bowel Disease through MALDI imaging mass spectrometry, Poster Presentation, CASMS Virtual Conference, August 28-31, 2023
• PeBenito, A., Scoggins IV, T. R., Prentice, B. M., Zackular J. P., Metabolic markers of C. difficile infection in the setting of Inflammatory Colitis, Poster Presentation, University of Pennsylvania Department of Medicine Research Day, June 13, 2023
• Scoggins IV, T. R., PeBenito, A., Specker, J. T., Zackular J. P., Prentice, B. M., Examining the metabolic factors promoting Clostridioides difficile infection in Inflammatory Bowel Disease through imaging mass spectrometry, Poster presentation, ID–315006, June 7, 2023, Proceedings of the 71st ASMS Conference on Mass Spectrometry and Allied Topics, Houston, TX, June 4-8, 2023.
• Scoggins IV, T. R., PeBenito, A., Specker, J. T., Zackular J. P., Prentice, B. M., Mapping the spatial metabolome of Clostridioides difficile infection in the presence of Inflammatory Bowel Disease., Poster Presentation, University of Florida Graduate Student Research Day, April 4, 2023
• Scoggins IV, T. R., Specker, J. T., Prentice, B. M., “Improving biomolecule detection in imaging mass spectrometry through selective gas phase enrichment,” Poster presentation, UF Chemistry-Biology Interface (CBI) Mini-symposium and Poster Session, Gainesville, FL, September 24, 2022.
• Scoggins IV, T. R., Specker, J. T., Prentice, B. M., “Multiple ion isolation and accumulation events for selective chemical noise reduction and dynamic range enhancement in MALDI imaging mass spectrometry,” Poster presentation, ID–310834, June 8, 2022, Proceedings of the 70th ASMS Conference on Mass Spectrometry and Allied Topics, Minneapolis, MN, June 5-9, 2022.