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Department of Chemistry College of Liberal Arts and Sciences
Picture of a current graduate student in the Prentice Lab

Yingchan Guo


Analytical Chemistry

Ph.D. 2026

Hometown
Yantai, Shandong, China

Education
B.S. in Chemistry, Beijing University of Chemical Technology (2020)

Contact
yingchanguo@ufl.edu

LinkedIn

Yingchan completed her B.S. in Chemistry at the Beijing University of Chemical Technology in 2020. She joined the Prentice lab in the fall of 2021 and received her Ph.D. in Analytical Chemistry with a minor in Computer Science at the University of Florida. Her research focuses on elucidating mechanisms and characterizing energy surfaces of gas-phase charge inversion ion/ion reactions in mass spectrometry, particularly for high-resolution mapping of lipids. She has extensive experience in cutting-edge mass spectrometry technologies, computational modeling, and developing machine learning and deep learning workflows for interpreting complex imaging mass spectrometry data. Her work aims to advance ion/ion reactions development and enhance spatial resolution in analytical characterization.

Awards

  • ASMS Graduate Student Award, American Society for Mass Spectrometry 2026
  • CLAS Dissertation Fellowship, Threadgill Scholarship Fund 2025
  • Tomas B. Hirschfeld Scholar Award, FACSS and SciX Conference 2025
  • Herbert A. and Marjorie G. Laitinen Graduate Fellowship, UF Chemistry Analytical Division 2025

Publications

  1. Smith, A.B. et al. mbio, 2023, 15, e01656-23. https://doi.org/10.1128/mbio.01656-23
  2. Ellin, N.R., Guo, Y. et al. Digital Discovery, 2024, 3, 805-817. https://doi.org/10.1039/D3DD00165B
  3. Liang, Z., Guo, Y. et al. Anal. Chem. 2024, 96, 29, 11869-11880. Multimodal image fusion workflow incorporating MALDI imaging mass spectrometry and microscopy for the study of small pharmaceutical compounds. https://doi.org/10.1021/acs.analchem.4c01553
  4. Liang, Z., Guo, Y. et al. Talanta, 2024, 274, 125923. https://doi.org/10.1016/j.talanta.2024.125923
  5. Bonney, J.R., Stratton, A.E., Guo, Y. et al. J. Am. Soc. Mass Spectrom. 2025, 36, 1, 119-126. Imaging mass spectrometry of sulfatide isomers from rat brain tissue using gas-phase charge inversion ion/ion reactions.  https://doi.org/10.1021/jasms.4c00368
  6. Scoggins, T.R., Guo, Y. et al. Anal. Chem. 2025, 97, 23, 12171-12179. Ozonolysis dissociation kinetics for the relative quantification geometrical phosphatidylcholine isomers. https://doi.org/10.1021/acs.analchem.5c00670
  7. Stratton, A.E., Moussa, H., Guo, Y. et al. Anal Bioanal Chem. 2025, 417, 4525-4535. A mass spectrometry-based assay for mouse IgG N-glycan screening in biofluids. https://doi.org/10.1007/s00216-025-05994-x
  8. Guo, Y.* et al. J. Am. Soc. Mass Spectrom. 2024, 35, 1797-1805. Enhancing spatial resolution in tandem mass spectrometry ion/ion reaction imaging experiments through image fusion. https://doi.org/10.1021/jasms.4c00144
  9. Guo, Y.* et al. J. Am. Soc. Mass Spectrom. 2025, 36, 10, 2103-2116. Characterizing the energy surfaces of competing pathways in gas-phase charge inversion ion/ion reactions involving cationized lipids and anionic diacids. https://doi.org/10.1021/jasms.5c00123
  10. Guo, Y.* et al. Accepted. J. Am. Soc. Mass Spectrom. Manipulation of gas-phase charge inversion ion/ion reaction kinetics for improved phospholipid identification in imaging mass spectrometry.

Teaching Experience

  • TA- CHM3120 – Introduction to Analytical Chemistry (UF, 2023)
  • TA- CHM2046L – General Chemistry and Qualitative Analysis Lab (UF, 2022)
  • TA- CHM2046L – General Chemistry and Qualitative Analysis Lab (UF, 2021)

Presentations

  1. Yingchan Guo*, et al. “Characterizing the Energy Surfaces of Competing Pathways in Gas-Phase Charge Inversion Ion/Ion Reactions”, 72nd ASMS Conference, Anaheim, CA, Jun 5, 2024.
  2. Troy R. Scoggins, IV, Yingchan Guo, et al. “Ozonolysis Kinetics for the Study of Lipid Cis/Trans Isomerism”, 6th Metabolomics Association of North America (MANA) Annual Conference, Tampa, FL, Oct 22, 2024.
  3. Yingchan Guo*, et al. “Characterizing mechanisms of proton, metal, and methyl transfer in gas-phase charge inversion ion/ion reactions involving lipids and diacids”, 73rd ASMS Conference, Baltimore, MD, Jun 3, 2025.
  4. Yingchan Guo* “Strategies for high chemical and high spatial resolution mapping of lipids via gas-phase ion/ion reactions in imaging mass spectrometry”, Amgen Chemistry Career Day, Jun 20, 2025.
  5. Yingchan Guo*, et al. ” Manipulation of gas-phase charge inversion ion/ion reaction kinetics for enhanced phospholipid identification in imaging mass spectrometry”, SciX 2025, Covington, KY, Oct 7, 2025.
  6. Yingchan Guo*, et al. “Characterizing mechanisms and energy surfaces of competing pathways in gas-phase ion/ion reactions involving lipids and diacids”, SciX 2025, Covington, KY, Oct 9, 2025.
  7. Zunaira Naeem, Yingchan Guo, Boone M. Prentice, “Exploring the mechanisms of radical directed dissociation enabled by novel cupric lipid ion types”, 74th ASMS Conference, San Diego, CA, Jun 1, 2026.
  8. Chen Du, Yingchan Guo, Victoria Cotham, Shunhai Wang, Ning Li, “A Perfect Coupling: Integrating Asymmetrical Flow Field-Flow Fractionation (AF4) with Charge Ddetection Mass Spectrometry (CDMS) to Resolve Biopharmaceutical Heterogeneity”, 74th ASMS Conference, San Diego, CA, Jun 3, 2026.

Posters

  1. Zhongling Liang, Nicholas Ellin, Yingchan Guo, et al. “Mapping Mitragyna speciosa alkaloids in rat brains using imaging mass spectrometry”, 70th ASMS Conference, Minneapolis, Jun 2, 2022.
  2. Yingchan Guo*, et al. “Computational modelling of reaction intermediates in gas-phase charge inversion ion/ion reactions”, 71st ASMS Conference, Houston, TX, Jun 5, 2023.
  3. Zhongling Liang, Yingchan Guo, Boone M. Prentice, “Compression of imaging mass spectrometry datasets using convolutional autoencoders”, 72nd ASMS Conference, Anaheim, CA, Jun 2-6, 2024.
  4. Mahshid Manouchehri, Yingchan Guo, et al. “Evaluation of novel clustering algorithms for identifying spatial patterns in imaging mass spectrometry”, 73rd ASMS Conference, Baltimore, MD, Jun 2, 2025.
  5. Elijah Mayo, et al. ” Iterative spatial resolution enhancement in imaging mass spectrometry via hydrogel tissue expansion and multimodal image fusion”, 73rd ASMS Conference, Baltimore, MD, Jun 3, 2025.
  6. Yingchan Guo*, Zhongling Liang, Tingting Yan, Boone M. Prentice, “Enhancing spatial resolution in MS/MS imaging experiments via computational image fusion”, SMSM Conference, FL, Mar 13, 2026.